Polynucleotides vs Profhilo: Which Treatment Is Right for You?

June 4, 2026
5 min read
Profhilo delivers rapid hydration and a plumping effect, while Polynucleotides focus on deeper tissue repair and regeneration. Together, they improve both immediate skin radiance and longer-term skin quality.

Polynucleotides and Profhilo are two of the most advanced injectable skin treatments available at The Oxley, both designed to improve skin quality from within. While they share a similar goal of creating healthier, more youthful-looking skin, they work in different ways and are suited to slightly different concerns.

Both treatments sit within a regenerative approach to aesthetics, focusing on hydration, texture, and overall skin health while maintaining natural-looking results and preserving your facial features.

How They Are Similar

Although they work differently in the skin, Polynucleotides and Profhilo both aim to improve overall skin quality rather than change facial structure. They stimulate the skin’s natural processes, helping to support collagen and elastin production while improving hydration and elasticity.

The result is fresher, smoother, and more radiant skin without adding volume or altering your natural appearance. Both treatments are also minimally invasive, with little downtime, making them a popular choice for subtle but effective rejuvenation.

Polynucleotides: Repair and Regeneration

Polynucleotides are injectable treatments made from purified DNA fragments that focus on repairing and regenerating the skin at a deeper cellular level. They work by supporting tissue healing and encouraging long-term skin renewal, helping to improve the overall health and quality of the skin over time.

They are particularly effective for areas that need delicate rejuvenation, such as under the eyes, where they can help improve dark circles, crepiness, and signs of fatigue. They also support improvements in skin tone, elasticity, and texture, making them ideal for patients looking to restore and strengthen the skin from within.

Results tend to develop gradually as the skin regenerates, leading to longer-lasting improvements in skin quality.

Profhilo: Hydration and Firmness

Profhilo is a highly concentrated hyaluronic acid injectable often referred to as an “injectable moisturiser.” Unlike dermal fillers, it does not add volume, but instead spreads beneath the skin to deeply hydrate and bio-remodel the tissue.

This intense hydration helps to improve firmness, elasticity, and overall skin glow. It is especially effective for areas showing signs of dehydration or laxity, such as the face, neck, and décolletage, where the skin may appear tired or less resilient.

Profhilo typically delivers a noticeable improvement in skin radiance and smoothness, with results building after a short course of treatments.

Can You Combine Them?

Yes, Polynucleotides and Profhilo can be combined for more comprehensive skin rejuvenation. Because they work in different ways, they complement each other well.

Profhilo provides rapid hydration and plumping, improving skin bounce and glow, while Polynucleotides work more deeply to repair tissue and support long-term regeneration. Together, they can address multiple signs of ageing, including dryness, fine lines, dullness, and loss of elasticity.

This combination approach is often recommended for patients looking to achieve both immediate skin improvement and longer-term skin health benefits.

Book Your Consultation at The Oxley

Choosing between Polynucleotides and Profhilo depends on your individual skin concerns and goals. In many cases, the best results come from a tailored treatment plan that combines both for layered, natural-looking rejuvenation.

At The Oxley, our practitioners will assess your skin and recommend the most effective approach for you. Book your consultation today to discover whether Polynucleotides, Profhilo, or a combination of both is right for your skin.